Effectiveness of glyceryl trinitrate (GTN) vasodilator patches in peripheral arterial disease
نویسنده
چکیده
Background Foot ulceration is caused by a variety of factors including ischemia. GTN is a nitric oxide donor that reliably causes vasodilation, but its potential to improve local vascular supply to at-risk feet has received little attention. When used to supplement standard evidence-based wound care, transdermal GTN produced rapid ulcer healing in four cases of non diabetic and diabetic ulcers. Subsequently, a larger study was conducted to investigate the effect of using small doses of GTN for therapeutic neurological and vascula outcomes in people with subnormal toe pressures.
منابع مشابه
Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat.
It has been reported that mitochondrial aldehyde dehydrogenase (ALDH2) catalyzes the formation of glyceryl dinitrate and inorganic nitrite from glyceryl trinitrate (GTN), leading to an increase in cGMP and vasodilation in the coronary and systemic vascular beds. However, the role of nitric oxide (NO) formed from nitrite in mediating the response to GTN in the pulmonary vascular bed is uncertain...
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